The new Russian Sanctions law (officially named the “Countering America’s Adversaries Through Sanctions Act”) is hardcore, but the worst of it may cripple the U.S. Space Program and harm U.S. national security and the U.S. economy. It all depends on how Russian President Putin decides to respond.
The most obvious target will be NASA and companies in the U.S. Defense Industrial Base that have significant contracts with Russian suppliers. The bill has a waiver for NASA.