More than 1,000 world leaders, celebrities, and other societal figures have signed a letter calling for an end to the “disastrous” drug war ahead of an upcoming United Nations summit to discuss the organization’s nearly two-decade-long campaign against narcotics.”

Humankind cannot afford a 21st century drug policy as ineffective and counterproductive as the last century’s,” reads the letter, organized by the Drug Policy Alliance (DPA), a drug reform advocacy group.