Folks looking to lose weight may turn to zero-calorie sweeteners like aspartame to cut calories. However, we discuss, aspartame can sabotage your efforts. The most obvious starting place seems to be switching from high-calorie foods with sugar to foods with zero calorie sweeteners, like aspartame. Better known by brand names, such as Equal, NutraSweet, and Spoonful, aspartame seems like a no-brainer. Fewer calories equals weight loss, right?